Aygestin

Aygestin (norethindrone) is a prescription progestin medication used to treat a range of gynecological and hormonal conditions. As a synthetic form of the natural hormone progesterone, it provides targeted hormonal regulation. It is commonly prescribed for abnormal uterine bleeding, amenorrhea, and endometriosis, and is also utilized in hormone replacement therapy and for endometrial protection during estrogen therapy. This product card provides a comprehensive, expert-level overview of its uses, dosing, safety profile, and clinical considerations.

Features

• Active ingredient: Norethindrone
• Dosage forms: Oral tablet (5 mg)
• Prescription-only medication
• Hormonal classification: Progestin
• Manufactured under strict pharmaceutical standards

Benefits

• Effectively manages abnormal uterine bleeding by regulating endometrial growth
• Provides symptomatic relief for endometriosis-associated pain
• Restores menstrual cycles in cases of secondary amenorrhea
• Offers endometrial protection during estrogen replacement therapy
• Provides reliable contraception when used as directed
• Helps manage symptoms of hormone imbalance

Common use

Aygestin is primarily indicated for the treatment of abnormal uterine bleeding due to hormonal imbalance without organic pathology. It is also prescribed for the management of endometriosis, often providing significant relief from associated pelvic pain and dysmenorrhea. Additionally, it is used to treat secondary amenorrhea and is incorporated into hormone replacement regimens to counteract estrogen-induced endometrial proliferation. Off-label uses may include management of premenstrual dysphoric disorder and certain cases of infertility, though these applications require careful medical supervision.

Dosage and direction

Dosage varies significantly based on the indication being treated. For abnormal uterine bleeding: 2.5-10 mg daily for 5-10 days during the second half of the menstrual cycle. For endometriosis: 5 mg daily for two weeks, increasing by 2.5 mg daily every two weeks until reaching 15 mg daily, maintained for 6-9 months. For amenorrhea: 2.5-10 mg daily for 5-10 days. Tablets should be taken at the same time each day, with or without food. Always follow the specific dosing regimen prescribed by your healthcare provider, as individual requirements may vary based on medical history and treatment response.

Precautions

Patients should undergo thorough medical evaluation before initiating Aygestin therapy. Regular monitoring of blood pressure, liver function, and cardiovascular status is recommended during treatment. Use with caution in patients with history of depression, as progestins may exacerbate mood disorders. Diabetic patients may require adjustment of hypoglycemic therapy. Patients should be advised that this medication may cause dizziness or drowsiness, affecting ability to operate machinery or drive. Long-term use requires periodic evaluation of bone mineral density in at-risk populations.

Contraindications

Aygestin is contraindicated in patients with known hypersensitivity to norethindrone or any component of the formulation. Additional contraindications include: known or suspected pregnancy, undiagnosed abnormal genital bleeding, history of or current thrombophlebitis or thromboembolic disorders, missed abortion, known or suspected breast carcinoma, active liver disease or dysfunction, and benign or malignant liver tumors. The medication is also contraindicated in patients with classic migraine headaches with focal neurological symptoms.

Possible side effect

Common side effects (≥1%) include nausea, headache, dizziness, breast tenderness, fluid retention, weight changes, and breakthrough bleeding. Less frequent adverse reactions may include mood changes, acne, hirsutism, alopecia, changes in libido, and gastrointestinal disturbances. Serious but rare side effects requiring immediate medical attention include: signs of thrombophlebitis (pain/swelling in calves, chest pain, sudden shortness of breath), severe headache, visual disturbances, jaundice, depression with suicidal ideation, and severe allergic reactions. Most side effects are dose-dependent and may diminish with continued use.

Drug interaction

Aygestin may interact with several medication classes. Hepatic enzyme inducers such as rifampin, barbiturates, carbamazepine, and phenytoin may decrease its effectiveness. Concurrent use with anticoagulants may require dosage adjustment. Insulin and oral hypoglycemic agents may need dosage modification. The effectiveness of Aygestin may be reduced when taken with St. John’s Wort. Conversely, Aygestin may affect the metabolism of cyclosporine, leading to increased plasma levels. Always inform your healthcare provider of all medications, including over-the-counter drugs and herbal supplements.

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for the missed one. The specific management of missed doses may vary based on the indication being treated. For contraceptive use, follow the specific missed dose instructions provided with the prescription. For other indications, contact your healthcare provider for guidance if multiple doses are missed or if uncertainty exists about how to proceed.

Overdose

There have been no reports of serious adverse effects from overdose. Large doses may cause nausea and vomiting, and withdrawal bleeding may occur in females. In case of suspected overdose, contact a poison control center or emergency room immediately. Treatment should be symptomatic and supportive. There is no specific antidote. Gastric lavage may be considered if ingestion was recent. Monitor vital signs and provide appropriate supportive care based on clinical presentation.

Storage

Store at controlled room temperature (20-25°C or 68-77°F), with excursions permitted between 15-30°C (59-86°F). Keep in the original container, tightly closed, and protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly discard any unused medication according to FDA-recommended disposal methods, preferably through a medicine take-back program.

Disclaimer

This information is provided for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting or changing any medication regimen. The information presented here may not be exhaustive or current. Actual product labeling and prescribing information should be consulted for complete details. Individual results may vary, and only a healthcare provider can determine the appropriate treatment based on individual medical circumstances.

Reviews

Clinical studies demonstrate Aygestin’s effectiveness in managing abnormal uterine bleeding, with approximately 85% of patients showing significant improvement in bleeding patterns. For endometriosis management, studies indicate pain reduction in 70-80% of patients after 6 months of therapy. Patient satisfaction surveys generally report positive experiences with symptom management, though individual experiences with side effects vary. Many healthcare providers consider it a valuable option in their therapeutic arsenal for hormonal management, particularly noting its predictable response profile and established safety data when used appropriately.