Besivance Ophthalmic Solution

Besivance (besifloxacin ophthalmic suspension) 0.6% is a prescription fluoroquinolone antimicrobial indicated for the treatment of bacterial conjunctivitis. Formulated specifically for ophthalmic use, it delivers potent, broad-spectrum bactericidal activity against common ocular pathogens, including resistant strains. Its innovative suspension base enhances corneal contact time and bioavailability, supporting effective microbial eradication and rapid symptomatic relief. Besivance is designed for topical administration and is suitable for patients aged 1 year and older.

Features

• Contains besifloxacin hydrochloride 0.6% (equivalent to 6 mg/mL besifloxacin)
• Preservative-free formulation in a sterile, white to off-white suspension
• Available in a 5 mL low-density polyethylene bottle with a controlled dropper tip
• pH approximately 6.8; osmolality approximately 260 to 330 mOsm/kg
• Broad-spectrum activity against Gram-positive, Gram-negative, and atypical bacteria
• Demonstrates low propensity for resistance development

Benefits

• Rapid and effective eradication of common bacterial pathogens causing conjunctivitis, including Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae
• High corneal penetration and sustained ocular surface contact for enhanced therapeutic efficacy
• Low incidence of systemic absorption, minimizing risk of systemic adverse effects
• Convenient twice-daily dosing regimen supports patient adherence
• Suitable for pediatric use (from 1 year of age) under appropriate supervision
• Reduces symptom duration and limits contagion potential through prompt bacterial clearance

Common use

Besivance is primarily prescribed for the treatment of bacterial conjunctivitis, an acute infection of the conjunctiva characterized by redness, discharge, eyelid edema, and discomfort. It is appropriate for cases where bacterial etiology is suspected or confirmed, particularly when broader-spectrum coverage is warranted due to regional resistance patterns or patient history. It may also be considered for perioperative prophylaxis in ocular surgery in select cases, though this is an off-label application.

Dosage and direction

• Instill one drop into the affected eye(s) twice daily, approximately 8 to 12 hours apart.
• Continue treatment for 7 days, or as directed by a healthcare provider, even if symptoms improve earlier.
• Wash hands before use. Avoid touching the dropper tip to any surface to prevent contamination.
• If using other topical ophthalmic products, administer them at least 5 minutes apart.
• Shake well before each use.

Precautions

• Not for injection or oral use. For topical ophthalmic use only.
• Contact lenses should not be worn during the course of treatment.
• Patients should discontinue use and consult a healthcare provider if symptoms worsen, or if ocular pain, vision changes, or persistent redness occur.
• Use with caution in patients with a history of hypersensitivity to fluoroquinolones or other product components.
• Fungal or viral superinfections may occur with prolonged use.

Contraindications

• Hypersensitivity to besifloxacin, other quinolones, or any component of the formulation.
• History of severe allergic reactions to fluoroquinolone antimicrobials.

Possible side effects

Common adverse reactions (occurring in 1–5% of patients) include:

• Blurred vision
• Eye irritation
• Eye pain
• Headache
• Redness

Less common side effects may include:

• Conjunctival hemorrhage
• Dry eye
• Eye pruritus
• Foreign body sensation
• Increased lacrimation

Rare but serious reactions include corneal deposits, allergic reactions, and phototoxicity.

Drug interaction

• No formal drug interaction studies have been conducted.
• Theoretical potential for interaction with cationic compounds (e.g., zinc, iron, magnesium) if administered systemically.
• Use caution when co-administering with other topical ophthalmic agents; allow sufficient time between applications.

Missed dose

If a dose is missed, administer it as soon as possible. If it is nearly time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Overdose

Topical overdose is unlikely to cause systemic effects due to minimal absorption. In case of accidental ingestion, seek medical attention. Ocular overdose may be rinsed gently with warm water.

Storage

• Store at 2°C to 25°C (36°F to 77°F).
• Keep the bottle tightly closed when not in use.
• Discard 30 days after opening.

Disclaimer

This information is intended for educational purposes and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis and treatment recommendations. Use only as directed by a prescribing physician.

Reviews

Clinical studies and post-marketing surveillance indicate high patient and clinician satisfaction with Besivance, citing rapid symptom resolution, tolerability, and convenience. In comparative trials, it demonstrated superior microbiological eradication rates versus older-generation fluoroquinolones. Some users note transient blurred vision post-application, though this typically resolves within minutes.