Orlistat: Clinically Proven Weight Management Therapy
Orlistat
| Product dosage: 120mg | |||
|---|---|---|---|
| Package (num) | Per cap | Price | Buy |
| 30 | $4.50 | $135.00 (0%) | 🛒 Add to cart |
| 60 | $4.03 | $270.00 $242.00 (10%) | 🛒 Add to cart |
| 90 | $3.87 | $405.00 $348.00 (14%) | 🛒 Add to cart |
| 120 | $3.79
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| Product dosage: 60mg | |||
|---|---|---|---|
| Package (num) | Per cap | Price | Buy |
| 30 | $1.97 | $59.00 (0%) | 🛒 Add to cart |
| 60 | $1.53 | $118.00 $92.00 (22%) | 🛒 Add to cart |
| 90 | $1.39 | $177.00 $125.00 (29%) | 🛒 Add to cart |
| 120 | $1.31 | $236.00 $157.00 (33%) | 🛒 Add to cart |
| 180 | $1.24 | $354.00 $223.00 (37%) | 🛒 Add to cart |
| 270 | $1.19 | $531.00 $322.00 (39%) | 🛒 Add to cart |
| 360 | $1.17
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Synonyms | |||
Orlistat is a lipase inhibitor medication approved for weight management in adults with obesity or overweight with related comorbidities. It functions by blocking the absorption of dietary fats in the intestines, thereby reducing caloric intake. This agent is indicated for use in conjunction with a reduced-calorie diet and is suitable for long-term weight control when combined with lifestyle modifications. Clinical evidence supports its efficacy in promoting weight loss and improving metabolic parameters.
Features
- Contains orlistat as the active pharmaceutical ingredient
- Available in 60 mg (over-the-counter) and 120 mg (prescription-only) formulations
- Inhibits gastrointestinal lipases, reducing fat absorption by approximately 30%
- Compatible with a hypocaloric, low-fat diet
- Non-systemic mode of action; minimal systemic absorption
Benefits
- Promotes clinically significant weight loss when used as part of a comprehensive weight management plan
- Helps reduce the risk of weight-related comorbidities such as type 2 diabetes and hypertension
- Supports long-term weight maintenance when combined with dietary and behavioral changes
- Provides a non-stimulant, non-central mechanism for weight control
- May improve lipid profiles and glycemic parameters in appropriate patient populations
Common use
Orlistat is commonly used for weight management in adults with an initial body mass index (BMI) of 30 kg/m² or greater, or 27 kg/m² or greater in the presence of other risk factors such as dyslipidemia, type 2 diabetes, or hypertension. It is intended as an adjunct to a reduced-calorie diet and should be used within the context of a comprehensive weight management program that includes regular physical activity and behavioral modification.
Dosage and direction
The recommended dosage of prescription-strength orlistat is 120 mg taken three times daily with each main meal containing fat. The over-the-counter formulation is taken as one 60 mg capsule three times daily with meals. Administration should occur during the meal or up to one hour after eating. If a meal is missed or contains no fat, the dose should be omitted. The medication should not be taken more than three times daily. Treatment should be discontinued if no meaningful weight loss occurs after 12 weeks.
Precautions
Patients should be advised to follow a nutritionally balanced, reduced-calorie diet containing approximately 30% of calories from fat. Distribution of daily fat, carbohydrate, and protein intake should be evenly divided across three main meals. A multivitamin supplement containing fat-soluble vitamins (A, D, E, K) should be taken once daily at least 2 hours before or after orlistat administration. Use with caution in patients with history of hyperoxaluria or calcium oxalate nephrolithiasis. Monitor renal function in patients at risk. Not recommended for use during pregnancy or breastfeeding.
Contraindications
Orlistat is contraindicated in patients with chronic malabsorption syndrome or cholestasis. It should not be used by patients with known hypersensitivity to orlistat or any component of the formulation. Use is contraindicated during pregnancy and in organ transplant recipients receiving cyclosporine therapy. Not recommended for use in pediatric populations or patients with anorexia nervosa or bulimia.
Possible side effects
The most common adverse effects are gastrointestinal in nature and result from increased fat excretion: oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation, and fecal incontinence. These effects are generally mild to moderate, decrease with continued use, and are associated with high-fat meals. Other reported effects include abdominal pain/discomfort, nausea, infectious diarrhea, rectal pain/discomfort, tooth/gum disorder, vomiting, and menstrual irregularity. Rare cases of severe liver injury have been reported.
Drug interaction
Orlistat may reduce absorption of fat-soluble vitamins (A, D, E, K) and beta-carotene. It may decrease plasma levels of amiodarone, cyclosporine, levothyroxine, antiepileptic drugs, and oral contraceptives. Patients taking these medications should separate administration by at least 2 hours. Orlistat may potentiate the anticoagulant effect of warfarin; monitor INR regularly. Concurrent use with acarbose is not recommended. May affect absorption of antiretroviral medications.
Missed dose
If a dose is missed, it should be skipped and the regular dosing schedule resumed with the next meal. Do not double the dose to make up for a missed administration. Consistent timing with meals optimizes therapeutic effect while minimizing gastrointestinal adverse events.
Overdose
There are no reports of serious adverse events from orlistat overdose. Single doses of 800 mg and multiple doses up to 400 mg three times daily for 15 days have been studied without significant adverse effects. Management should be symptomatic and supportive. In cases of significant overdose, monitor for possible gastrointestinal effects and ensure adequate hydration.
Storage
Store at room temperature between 15°C and 30°C (59°F and 86°F). Keep in the original container with the cap tightly closed to protect from moisture. Do not store in bathroom cabinets where humidity levels may fluctuate. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Individual responses to medication may vary. Consult with a qualified healthcare professional before starting any new medication or weight management program. Proper diagnosis and supervision are essential for safe and effective treatment. Not all possible uses, interactions, or adverse effects are included here.
Reviews
Clinical trials demonstrate that orlistat produces significantly greater weight loss compared to placebo when combined with lifestyle modification. In a 4-year study, orlistat plus lifestyle intervention resulted in greater weight loss maintenance and reduced incidence of type 2 diabetes compared to placebo. Systematic reviews confirm its efficacy for weight management with a favorable risk-benefit profile when used appropriately. Patient satisfaction varies, with gastrointestinal effects being the most commonly reported reason for discontinuation. Long-term data support its safety profile when used as directed under medical supervision.