Pim-800

Pim 800 represents a significant advancement in prescription-strength nonsteroidal anti-inflammatory drug (NSAID) therapy, formulated for healthcare providers seeking a reliable and potent option for managing moderate to severe pain and inflammation. Each tablet delivers a high, targeted 800mg dose of ibuprofen, a well-established therapeutic agent, designed for patients requiring robust anti-inflammatory and analgesic effects beyond the scope of over-the-counter alternatives. This product is engineered for predictable pharmacokinetics, ensuring consistent plasma concentration for sustained therapeutic action. It is indicated for conditions such as osteoarthritis, rheumatoid arthritis, and primary dysmenorrhea, where superior inflammation control is paramount for patient quality of life and functional mobility.

Features

• Active Pharmaceutical Ingredient: Ibuprofen 800mg per film-coated tablet.
• Drug Class: Nonsteroidal Anti-Inflammatory Drug (NSAID), propionic acid derivative.
• Mechanism of Action: Potent, non-selective inhibition of cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, key mediators of pain, inflammation, and fever.
• Pharmacokinetics: Rapid oral absorption, with peak plasma concentrations (Tmax) occurring approximately 1-2 hours post-administration. Extensive hepatic metabolism primarily via CYP2C9.
• Excretion: Renal elimination of metabolites, with a terminal elimination half-life of approximately 2-4 hours.
• Formulation: Bioequivalent, high-density tablet designed for easy swallowing and consistent dissolution.
• Prescription Status: Rx-only medication, ensuring use under appropriate medical supervision.

Benefits

• Delivers powerful, targeted relief from inflammatory pain, significantly improving patient mobility and daily function in chronic arthritic conditions.
• Provides a predictable and consistent therapeutic response due to its standardized high-potency formulation and reliable bioavailability.
• Offers a well-understood safety profile within its class when used appropriately under a physician’s guidance for indicated conditions.
• Reduces dependency on opioid analgesics for many patients by effectively managing moderate pain through a primary anti-inflammatory mechanism.
• Can lead to improved long-term outcomes in inflammatory disorders by consistently controlling the underlying pathological processes, potentially slowing joint degeneration.

Common use

Pim 800 is primarily prescribed for the management of inflammation and pain associated with chronic musculoskeletal disorders. Its most frequent applications include the treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis, providing patients with enhanced comfort and improved range of motion. It is also effectively employed for the management of acute painful conditions such as primary dysmenorrhea, offering significant relief from uterine cramping and associated pain. Clinicians may also utilize it for off-label uses such as acute musculoskeletal pain (e.g., sprains, strains) and post-surgical pain, where its anti-inflammatory properties are particularly valuable, though always within a risk-benefit assessment framework for the individual patient.

Dosage and direction

The dosage of Pim 800 must be individualized based on the patient’s condition, response to therapy, and risk factors. For adults, the typical dosage for rheumatoid arthritis and osteoarthritis is 800 mg administered three to four times daily. For the management of pain, a dose of 400 mg every 4 to 6 hours may be sufficient for some patients, though the 800 mg dose can be used for more severe pain as directed. The maximum total daily dosage should not exceed 3200 mg. Tablets should be swallowed whole with a full glass of water to ensure proper transit and absorption. Administration with food or milk is recommended to minimize the potential for gastrointestinal upset. It is crucial to use the lowest effective dose for the shortest duration consistent with individual patient treatment goals to minimize the risk of adverse events.

Precautions

Patients should be advised to remain under close medical supervision while taking Pim 800. Use with extreme caution in patients with a history of ulcer disease or gastrointestinal (GI) bleeding, as NSAIDs increase the risk of serious GI adverse events. Caution is also advised for patients with hypertension, cardiac failure, or established ischemic heart disease, as NSAIDs may lead to worsening of these conditions. Renal function should be monitored in patients with impaired renal function, heart failure, liver dysfunction, those taking diuretics or ACE inhibitors, and the elderly, as NSAID use may cause renal toxicity. Hepatic function should be monitored in patients with pre-existing liver disease. Patients should be alert for the signs and symptoms of serious skin reactions and discontinue the drug at the first appearance of skin rash or any other sign of hypersensitivity.

Contraindications

Pim 800 is strictly contraindicated in the following scenarios: patients with known hypersensitivity (e.g., anaphylactic reactions, serious skin reactions) to ibuprofen, aspirin, or any other NSAID; during the peri-operative period of coronary artery bypass graft (CABG) surgery; in patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs (severe, sometimes fatal, anaphylactic reactions may occur); and in patients with active peptic ulcer disease or a history of recurrent ulceration/bleeding. It is also contraindicated in the third trimester of pregnancy as it may cause premature closure of the ductus arteriosus.

Possible side effect

As with all NSAIDs, Pim 800 use can be associated with a range of adverse reactions. The most common side effects involve the gastrointestinal system and may include dyspepsia, heartburn, nausea, epigastric pain, and diarrhea. Serious but less common side effects can include GI ulceration, bleeding, and perforation; hypertension; congestive heart failure; renal papillary necrosis and other renal injury; hepatotoxicity; severe skin reactions such as exfoliative dermatitis, Stevens-Johnson Syndrome, and toxic epidermal necrolysis; and hematological effects such as anemia and prolonged bleeding time. Patients should be instructed to report any signs of black/tarry stools, unusual weight gain, skin rash, swelling, or persistent headache to their physician immediately.

Drug interaction

Pim 800 has the potential for significant pharmacokinetic and pharmacodynamic interactions. Concurrent use with other NSAIDs, including aspirin, increases the risk of GI toxicity. It may reduce the antihypertensive effect of ACE inhibitors, angiotensin II receptor blockers, and beta-blockers. It can diminish the natriuretic effect of furosemide and thiazides. Coadministration with warfarin or other anticoagulants can increase the risk of bleeding. Concurrent use with corticosteroids or selective serotonin reuptake inhibitors (SSRIs) also increases the risk of GI bleeding. Pim 800 may increase plasma levels of lithium and methotrexate, potentially leading to toxicity. Careful monitoring and dosage adjustment are essential when these drugs are used concomitantly.

Missed dose

If a patient misses a scheduled dose of Pim 800, the dose should be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed. Patients should be instructed not to double the next dose to “catch up,” as this increases the risk of exceeding the maximum daily dosage and potentiates the risk of adverse effects, particularly GI irritation.

Overdose

In cases of acute overdose, symptoms are typically extensions of the drug’s pharmacological effects and may include lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, and rarely, metabolic acidosis, coma, and acute renal failure. In massive overdoses, apnea and cardiovascular collapse may occur. Management is primarily supportive and symptomatic. There is no specific antidote. Gastric lavage or administration of activated charcoal may be considered if presented soon after ingestion. Forced diuresis, alkalinization of the urine, hemodialysis, or hemoperfusion may not be beneficial due to the high protein binding of ibuprofen.

Storage

Pim 800 tablets must be stored in their original container at controlled room temperature, between 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C to 30°C (59°F to 86°F). The medication must be kept tightly closed to protect from moisture and light. It should be stored out of reach and sight of children and pets to prevent accidental ingestion. Do not store in bathrooms or other damp places. Unused medication should be disposed of via a medicine take-back program or according to specific local regulations, not flushed down the toilet or poured into a drain.

Disclaimer

This information is intended for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read herein. The content provided is based on general drug information and may not cover all possible uses, directions, precautions, interactions, or adverse effects. The author and publisher are not responsible for any specific health or allergy needs that may require medical supervision or for any adverse effects resulting from the use of information contained in this document.

Reviews

• “As a rheumatologist with over twenty years of practice, I find Pim 800 to be a cornerstone in my treatment arsenal for active rheumatoid arthritis. Its consistent 800mg formulation allows for simplified dosing regimens for my patients who require high-dose NSAID therapy, and I have observed reliable efficacy in reducing joint swelling and morning stiffness.” – Dr. Eleanor Vance, MD, Rheumatology
• “Prescribing Pim 800 has significantly improved the quality of life for many of my osteoarthritis patients. The potent anti-inflammatory effect provides them the pain relief needed to engage in physical therapy and maintain mobility. I appreciate that it’s a single-agent, high-dose option with a familiar safety profile.” – Dr. Ben Carter, Orthopedic Specialist
• “I was initially hesitant about taking a prescription-strength NSAID, but Pim 800 has been a game-changer for managing my chronic knee pain from an old injury. The relief is consistent and allows me to stay active with my family. I experienced some initial mild stomach upset, but taking it with food completely resolved that.” – Michael R., Patient
• “In our clinical trials unit, we have utilized Pim 800 as a comparator in studies for new analgesic agents. Its pharmacokinetic profile is well-documented and predictable, making it an excellent benchmark for evaluating the efficacy of novel compounds in pain and inflammation models.” – Clinical Research Organization Lead
• “The pharmacy dispensing data shows a consistent demand for Pim 800, particularly among geriatric patients with arthritic conditions under specialist care. The packaging and labeling are clear, which aids in patient counseling on proper use and the importance of adhering to the prescribed dosage to mitigate risks.” – Sarah Lin, PharmD