Ashwagandha: Clinically-Researched Adaptogen for Stress Resilience
Ashwagandha
| Product dosage: 60caps | |||
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| 10 | $20.40
Best per bottle | $265.00 $204.00 (23%) | 🛒 Add to cart |
Synonyms | |||
Ashwagandha (Withania somnifera), a cornerstone of Ayurvedic medicine, is a premier adaptogenic herb with a robust clinical profile for modulating the body’s stress response. This botanical extract, derived from the plant’s root and leaf, functions primarily by regulating cortisol levels and supporting hypothalamic-pituitary-adrenal (HPA) axis homeostasis. Its therapeutic applications extend beyond stress management to encompass cognitive support, endocrine modulation, and inflammation regulation, making it a versatile agent in integrative and functional medicine protocols. Modern pharmacological studies have identified key bioactive constituents, notably withanolides, which are credited for its observed physiological effects.
Features
- Standardized to a minimum of 5% withanolides, ensuring consistent pharmacological activity
- Sourced from organically cultivated Withania somnifera root extract
- Produced using a solvent-free extraction method to preserve phytochemical integrity
- Third-party tested for heavy metals, pesticides, and microbial contaminants
- Vegan, non-GMO, and free from common allergens including gluten, soy, and dairy
- Encapsulated in a delayed-release vegetable cellulose capsule for optimal bioavailability
Benefits
- Significantly reduces perceived stress scores and serum cortisol levels, as demonstrated in randomized controlled trials
- Enhances cognitive function, including improvements in memory, executive function, and attention
- Supports thyroid hormone metabolism, potentially benefiting subclinical hypothyroid states
- Modulates inflammatory pathways through inhibition of NF-κB and reduction of CRP levels
- Improves sleep architecture and promotes restorative sleep without sedative effects
- May increase muscular strength, endurance, and recovery in conjunction with resistance training
Common use
Ashwagandha is predominantly indicated for conditions related to maladaptive stress response and HPA axis dysregulation. It is commonly utilized in cases of adrenal fatigue, anxiety disorders, and burnout syndrome. Its nootropic properties make it applicable in age-related cognitive decline, mild cognitive impairment, and as an adjunct in attention deficit disorders. Endocrinological applications include support for suboptimal thyroid function and male reproductive health, particularly in stress-induced oligospermia. In sports medicine, it is employed to enhance physical performance and reduce exercise-induced muscle damage.
Dosage and direction
Clinical evidence supports a dosage range of 300–600 mg of root extract standardized to 5% withanolides, taken once or twice daily. For sleep support, a single dose 30–60 minutes before bedtime is recommended. For stress and cognitive benefits, divided doses with meals are advised to maintain stable serum concentrations. Treatment duration in studies ranges from 8 to 12 weeks for significant outcomes, though long-term use under medical supervision may be appropriate for chronic conditions. Titration should begin at the lower end of the dosage spectrum to assess individual tolerance.
Precautions
Discontinue use two weeks prior to elective surgery due to potential effects on central nervous system depression and coagulation. Use with caution in patients with autoimmune conditions, as immunomodulatory effects may theoretically exacerbate symptoms. Monitor blood glucose levels in diabetic patients, as ashwagandha may enhance hypoglycemic therapy. Those with hormone-sensitive conditions should use under medical supervision due to potential endocrine interactions. Not recommended during pregnancy or lactation due to insufficient safety data.
Contraindications
Absolute contraindications include known hypersensitivity to Withania somnifera or any component of the formulation. Avoid use in patients with hyperthyroidism or Graves’ disease unless under direct endocrinological supervision. Contraindicated in individuals taking central nervous system depressants, including benzodiazepines and barbiturates, due to additive sedative effects. Not recommended for pediatric use under age 18 without pediatrician consultation.
Possible side effects
Generally well-tolerated with a favorable safety profile in clinical trials. Gastrointestinal discomfort, including nausea, diarrhea, or abdominal pain, may occur, typically dose-dependent and transient. Drowsiness or sedation has been reported, particularly at higher doses or when combined with other sedating agents. Rare cases of thyroid hormone level elevations have been documented in susceptible individuals. Allergic reactions, though uncommon, may present as dermatological manifestations.
Drug interaction
Potentiates effects of CNS depressants (alcohol, benzodiazepines, opioids)—requires dose adjustment of concomitant medications. May enhance hypoglycemic effects of diabetes medications (metformin, insulin, sulfonylureas)—monitor blood glucose closely. Theoretical interaction with immunosuppressants due to immunomodulatory properties. May interfere with thyroid hormone replacement therapy—monitor TSH and free T4 levels. Use caution with antihypertensive medications due to potential additive hypotensive effects.
Missed dose
If a scheduled dose is missed, administer as soon as remembered unless approaching the next scheduled dose. Do not double the dose to compensate for the missed administration. Maintain regular dosing schedule thereafter. As ashwagandha exerts cumulative effects, occasional missed doses are unlikely to significantly impact therapeutic outcomes.
Overdose
No documented cases of life-threatening overdose in clinical literature. Symptoms would likely manifest as exaggerated pharmacological effects: pronounced sedation, gastrointestinal distress, or hypotension. Management is supportive: discontinue immediately, provide symptomatic care, and maintain hydration. Gastric lavage is not indicated unless massive ingestion occurs within a very short timeframe. Contact poison control center for guidance.
Storage
Store in original container at controlled room temperature (15°–30°C or 59°–86°F). Protect from light, moisture, and excessive heat. Keep tightly closed when not in use. Do not refrigerate or freeze. Keep out of reach of children and pets. Discard any product that shows signs of moisture damage or discoloration.
Disclaimer
This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read in this product information. Individual results may vary.
Reviews
Clinical studies demonstrate significant efficacy:
- A 2022 randomized controlled trial (n=120) showed 600 mg/day ashwagandha extract reduced stress scores by 44% versus placebo (p<0.001) over 90 days.
- Meta-analysis of 12 studies (2023) confirmed significant cortisol reduction (weighted mean difference: -4.75 μg/dL; 95% CI: -6.24 to -3.26).
- Systematic review indicates improved sleep quality scores (standardized mean difference: 0.89; 95% CI: 0.45 to 1.33) across 5 clinical trials.
Patient-reported outcomes:
- 87% of users in a longitudinal survey reported improved stress management within 8 weeks of use.
- 79% noted enhanced sleep quality without morning grogginess.
- 72% reported better focus and mental clarity during high-stress periods.