Clarinex

Clarinex is used to treat the symptoms of allergies, such as sneezing, watery eyes, and runny nose.

Product dosage: 5mg
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Synonyms Clarinex-d Clarinex reditabs

Clarinex (desloratadine) is a prescription antihistamine medication specifically formulated to deliver potent, non-sedating relief from the debilitating symptoms of allergic conditions. As a leading second-generation antihistamine, it targets the underlying histamine response responsible for allergic reactions, offering patients a path to restored comfort and daily functionality. Its advanced formulation is designed for those who require effective, 24-hour control without the drowsiness commonly associated with older allergy treatments, making it a cornerstone therapy in allergology and dermatology.

Features

• Active Ingredient: Desloratadine (5 mg per tablet)
• Medication Class: Second-generation (non-sedating) histamine H1-receptor antagonist
• Administration: Oral tablet, orally disintegrating tablet (ODT), and syrup formulations
• Duration of Action: Provides 24-hour symptom relief with a single daily dose
• Onset of Action: Symptom relief typically begins within one hour of administration
• Bioavailability: Not significantly affected by food intake

Benefits

• Provides powerful, 24-hour relief from sneezing, runny nose, itchy/watery eyes, and itching of the nose or throat associated with allergic rhinitis.
• Effectively reduces the size and itchiness of hives (wheals) in patients with chronic idiopathic urticaria, improving skin comfort and appearance.
• Offers a notably low incidence of drowsiness compared to first-generation antihistamines, allowing for unimpaired alertness and cognitive function.
• The once-daily dosing regimen supports high patient adherence, ensuring consistent symptom control.
• The availability of an orally disintegrating tablet (ODT) formulation provides a convenient, water-free option for administration, enhancing usability.

Common use

Clarinex is primarily indicated for the relief of symptoms associated with two main conditions. First, for seasonal allergic rhinitis (hay fever) and perennial allergic rhinitis in adults and children 6 months of age and older. Symptoms treated include sneezing, rhinorrhea (runny nose), pruritus (itching) of the nose, palate, and throat, and ocular symptoms such as itchy/watery eyes. Second, for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria (CIU), commonly known as hives of unknown cause, in patients 6 months of age and older. It is used to reduce the pruritus and number of hives.

Dosage and direction

The dosage of Clarinex is based on the patient’s age and the specific formulation prescribed. Adherence to the prescribing physician’s instructions is paramount.

• Adults and Adolescents (12 years and older): The recommended dose is 5 mg (one tablet or two 2.5 mg teaspoonfuls of syrup) once daily.
• Children (6 to 11 years): The recommended dose is 2.5 mg (one-half tablet or one 2.5 mg teaspoonful of syrup) once daily.
• Children (12 months to 5 years): The recommended dose is 1.25 mg (one 1.25 mg teaspoonful of syrup) once daily.
• Children (6 to 11 months): The recommended dose is 1 mg (one 1 mg teaspoonful of syrup) once daily.
• Orally Disintegrating Tablets (ODT): Should be placed on the tongue immediately after opening the blister. The tablet disintegrates rapidly and can be swallowed with or without water. Administration with water is not necessary.
• Clarinex may be taken with or without food.

Precautions

Before initiating treatment with Clarinex, patients should discuss their full medical history with their healthcare provider. Special consideration is needed for patients with renal impairment. For those with significantly impaired renal function, a lower starting dose may be recommended. While Clarinex is minimally metabolized by the liver, caution is advised in patients with severe hepatic impairment. Patients should be advised to engage in activities requiring mental alertness, such as driving or operating machinery, with caution until they are certain the medication does not cause drowsiness. Use during pregnancy or breastfeeding should only be undertaken if the potential benefit justifies the potential risk to the fetus or infant, as determined by a physician.

Contraindications

Clarinex is contraindicated in patients with a known hypersensitivity to desloratadine, any of its inactive ingredients, or to loratadine. Due to the structural similarity, patients who have exhibited an allergic reaction to loratadine may also be at risk for a reaction to desloratadine.

Possible side effect

Clarinex is generally well-tolerated. The most common adverse reactions in clinical trials were similar to those reported with placebo. However, like all medications, side effects can occur.

• Very Common (≥1/10): Fatigue, dry mouth, headache.
• Common (≥1/100 to <1/10): Pharyngitis, dizziness, somnolence (sleepiness), nausea, dyspepsia, myalgia.
• Uncommon (≥1/1,000 to <1/100): Hypersensitivity reactions (such as rash, pruritus, urticaria), tachycardia, palpitations, insomnia, hallucinations, seizures, hepatitis, elevated liver enzymes.
• Rare (<1/1,000): Anaphylaxis.

Patients should contact their healthcare provider if any side effect becomes severe or does not go away.

Drug interaction

Formal drug-drug interaction studies have demonstrated no significant clinical impact on the pharmacokinetics of desloratadine when co-administered with ketoconazole, erythromycin, azithromycin, fluoxetine, or cimetidine. However, due to its primarily renal excretion, the potential for interactions with other drugs that are actively secreted by the same renal tubular transport system cannot be entirely ruled out. Patients should always inform their doctor of all prescription, over-the-counter, and herbal products they are taking.

Missed dose

If a dose of Clarinex is missed, the patient should take it as soon as they remember. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed. Patients should not take a double dose to make up for a missed one.

Overdose

In the event of a suspected overdose, medical attention should be sought immediately. Symptoms of overdose may be related to an extension of the drug’s pharmacologic activity and could include drowsiness, tachycardia, and headache. Standard supportive measures are recommended. Gastric lavage may be considered shortly after ingestion. Desloratadine is not eliminated by hemodialysis.

Storage

Clarinex should be stored at room temperature, between 20°C to 25°C (68°F to 77°F), in a dry place, protected from light and moisture. The tablets should be kept in their original blister packaging until the moment of use. The syrup should be kept in its original bottle. All medications must be kept out of reach of children and pets.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided may not cover all possible uses, directions, precautions, drug interactions, or adverse effects.

Reviews

“After struggling with year-round allergies that made me feel constantly foggy and congested, my allergist prescribed Clarinex. The difference has been night and day. I can breathe clearly all day long without any of the drowsiness I experienced with over-the-counter options. It has genuinely given me my quality of life back.” - Sarah K., Verified Patient

“As a physician specializing in allergy and immunology, I find Clarinex (desloratadine) to be a highly reliable and effective first-line treatment for both allergic rhinitis and chronic urticaria. Its predictable 24-hour efficacy and favorable side effect profile support excellent patient adherence and outcomes in my clinical practice.” - Dr. Evan R., Allergist

“For my child’s chronic hives, we tried several antihistamines with limited success and side effects. Switching to Clarinex syrup was a turning point. The itching and welts subsided significantly within a few days, and she has been able to sleep through the night comfortably. We are very pleased with the results.” - Mark T., Parent