Copegus

Copegus is used to treat chronic hepatitis C.

Product dosage: 200mg
Package (num)	Per cap	Price	Buy
30	$5.70	$171.00 (0%)	🛒 Add to cart
60	$5.18	$342.00 $311.00 (9%)	🛒 Add to cart
90	$5.02 Best per cap	$513.00 $452.00 (12%)	🛒 Add to cart
Synonyms Ribasphere Rebetol Ribapak Ribatab

Copegus is a critical antiviral medication formulated as ribavirin, designed for use in combination therapy to treat chronic hepatitis C virus (HCV) infection. As a nucleoside analogue, it inhibits viral replication by interfering with RNA synthesis, significantly enhancing sustained virologic response rates when paired with peginterferon alfa or newer direct-acting antivirals. Its role is foundational in reducing viral load, preventing progression to cirrhosis, and decreasing the risk of hepatocellular carcinoma. Proper adherence to prescribed regimens under medical supervision is essential to maximize efficacy and manage potential side effects.

Features

• Active ingredient: Ribavirin 200 mg
• Available in film-coated tablet form
• Pack sizes: 84, 168, or 240 tablets
• Requires combination therapy with peginterferon alfa or DAAs
• Manufactured under strict pharmaceutical compliance (GMP)
• Prescription-only medication

Benefits

• Significantly increases sustained virologic response (SVR) rates in HCV patients
• Reduces risk of liver fibrosis, cirrhosis, and hepatocellular carcinoma
• Helps achieve viral clearance, improving long-term liver function
• Compatible with various interferon-based and interferon-free regimens
• Contributes to lowered HCV transmission rates
• Supports comprehensive HCV genotype-specific treatment strategies

Common use

Copegus is indicated for the treatment of chronic hepatitis C in combination with other antiviral agents such as peginterferon alfa-2a or direct-acting antivirals (DAAs). It is used in adult patients with compensated liver disease, including those with previously untreated, relapsed, or non-respondent HCV. Treatment is tailored according to HCV genotype, viral load, and patient history, often spanning 24 to 48 weeks based on individual response and guidelines.

Dosage and direction

Dosage is weight-based and genotype-dependent:

• Genotype 1 or 4: <75 kg: 1000 mg/day; ≥75 kg: 1200 mg/day (in divided doses)
• Genotype 2 or 3: 800 mg/day in divided doses
• Administer orally with food to improve absorption
• Duration typically 24 weeks for genotypes 2/3 and 48 weeks for genotypes 1/4, unless using DAA combinations where duration may vary
• Always combine with peginterferon alfa or approved DAAs as directed

Precautions

• Pregnancy must be avoided by both female patients and female partners of male patients due to teratogenic risks; two forms of contraception are required
• Regular monitoring of hematologic parameters (hemoglobin, neutrophils, platelets) is essential
• Use with caution in patients with cardiac disease, history of depression, or autoimmune disorders
• Assess renal and hepatic function before and during treatment
• Educate patients on adherence and potential side effects

Contraindications

• Pregnancy or planned pregnancy in patient or partner
• History of severe cardiac disease
• Hemoglobinopathies (e.g., thalassemia, sickle-cell anemia)
• Severe hepatic impairment or decompensated cirrhosis
• Autoimmune hepatitis
• Hypersensitivity to ribavirin or any component of the formulation

Possible side effect

• Hemolytic anemia (dose-related)
• Fatigue, headache, nausea
• Insomnia, irritability, depression
• Rash, pruritus
• Cough, dyspnea
• Thyroid dysfunction
• Increased uric acid levels

Drug interaction

• Didanosine: contraindicated due to risk of fatal hepatic failure
• Zidovudine: may potentiate hematologic toxicity
• Azathioprine: increased risk of pancytopenia
• Monitor with other myelosuppressive agents

Missed dose

If a dose is missed, take it as soon as remembered on the same day. If the day has passed, skip the missed dose and resume the regular schedule. Do not double the dose.

Overdose

Symptoms may include exacerbation of side effects, particularly hematologic toxicity. There is no specific antidote; management is supportive and may include discontinuation of therapy and hematologic monitoring.

Storage

Store at room temperature (15–30°C). Keep in the original container, tightly closed, and away from moisture and light. Keep out of reach of children and pets.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized medical guidance. Use only as prescribed.

Reviews

Clinical studies and patient reports indicate that Copegus, in combination therapy, contributes to high SVR rates and improved quality of life for many HCV patients. Adherence to the regimen and regular monitoring are frequently emphasized as keys to success.