Luvox

Luvox is indicated for the treatment of obsessions and compulsions in patients with obsessive compulsive disorder (OCD).

Product dosage: 100mg
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Product dosage: 50mg
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Synonyms Luvox cr

Luvox (fluvoxamine maleate) is a selective serotonin reuptake inhibitor (SSRI) approved by the FDA for the treatment of obsessive-compulsive disorder (OCD) in both adult and pediatric populations. It functions by increasing the availability of serotonin in the brain, a neurotransmitter critically involved in mood regulation, anxiety, and repetitive behaviors. With a well-established efficacy profile and extensive clinical research supporting its use, Luvox represents a first-line pharmacological option for managing the intrusive thoughts and compulsive rituals characteristic of OCD. Its targeted mechanism offers a balance of potency and tolerability for appropriate patients under professional supervision.

Features

• Active Ingredient: Fluvoxamine maleate
• Drug Class: Selective Serotonin Reuptake Inhibitor (SSRI)
• Available Forms: Immediate-release tablets (25 mg, 50 mg, 100 mg) and extended-release capsules
• FDA-Approved Indications: Obsessive-Compulsive Disorder (adults and children aged 8–17)
• Off-Label Uses: Social anxiety disorder, panic disorder, depression, post-traumatic stress disorder (PTSD)
• Half-Life: Approximately 15–22 hours
• Time to Steady State: About 7–10 days of consistent dosing
• Metabolism: Primarily hepatic, via CYP450 enzymes (CYP1A2, CYP2D6, CYP3A4)

Benefits

• Reduces OCD Symptom Severity: Clinically proven to decrease the frequency and intensity of obsessive thoughts and compulsive behaviors.
• Improves Daily Functioning: Helps restore the ability to perform routine tasks without interference from ritualistic behaviors.
• Enhances Quality of Life: Supports better social, occupational, and academic engagement by alleviating anxiety-driven behaviors.
• Flexible Dosing Options: Available in multiple strengths and formulations to allow for individualized titration.
• Pediatric Application: One of the few SSRIs approved for use in children and adolescents with OCD.
• Non-Sedating Profile: Unlike some older antidepressants, it generally does not cause significant daytime drowsiness.

Common use

Luvox is primarily prescribed for the management of obsessive-compulsive disorder. Its use is supported by numerous randomized controlled trials demonstrating significant reductions in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores. It is also used off-label for other anxiety disorders, including social anxiety and panic disorder, as well as major depressive disorder, though it is not FDA-approved for these conditions. In clinical practice, it may be selected over other SSRIs for patients who have not responded adequately to first-line options or who present with particular symptom profiles, such as prominent anxiety or comorbid conditions.

Dosage and direction

Dosage must be individualized based on patient response, tolerance, and indication. For adults with OCD, the recommended starting dose is 50 mg once daily at bedtime, which may be increased in 50 mg increments every 4–7 days as tolerated. The effective dosage range is typically 100–300 mg/day, administered in divided doses or as a single daily dose depending on formulation and tolerability. For pediatric patients (ages 8–17), the starting dose is 25 mg daily, with a target range of 50–200 mg/day. Doses above 50 mg/day should be divided. Luvox should be taken with food to minimize gastrointestinal upset. Dosage adjustments are necessary in patients with hepatic impairment.

Precautions

• Monitor for emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, impulsivity, and suicidality, especially during initial treatment and dose adjustments.
• Use with caution in patients with a history of mania/hypomania or seizure disorders.
• May cause hyponatremia; monitor sodium levels in elderly patients, those on diuretics, or those who are volume-depleted.
• Discontinuation should be gradual to avoid withdrawal symptoms (e.g., dizziness, nausea, headache, irritability).
• Inform patients that full therapeutic effect may take 4–8 weeks to manifest.
• Caution advised when operating machinery or driving until the patient’s response is known.

Contraindications

• Hypersensitivity to fluvoxamine or any component of the formulation.
• Use of monoamine oxidase inhibitors (MAOIs) concurrently or within 14 days of discontinuing Luvox due to risk of serotonin syndrome.
• Use of thioridazine or pimozide due to risk of QT prolongation and serious arrhythmias.
• Use with alosetron due to increased plasma concentrations and risk of serious gastrointestinal adverse events.

Possible side effect

Common side effects (≥5%) include nausea, somnolence, insomnia, asthenia, dizziness, constipation, anorexia, nervousness, dry mouth, sweating, and abnormal ejaculation. Less common but serious adverse reactions may include serotonin syndrome, suicidal thoughts and behaviors in young adults, abnormal bleeding, angle-closure glaucoma, mania, seizures, and syndrome of inappropriate antidiuretic hormone secretion (SIADH). Sexual dysfunction, including decreased libido and anorgasmia, may occur and persist post-discontinuation in some cases.

Drug interaction

Luvox is a potent inhibitor of CYP1A2 and CYP2C19 and a moderate inhibitor of CYP2D6 and CYP3A4, leading to numerous clinically significant interactions. It increases concentrations of: theophylline, clozapine, olanzapine, methadone, warfarin, benzodiazepines (e.g., alprazolam), tricyclic antidepressants, and propranolol. Concurrent use with NSAIDs, aspirin, or other drugs affecting coagulation may increase bleeding risk. Avoid use with serotonergic drugs (e.g., tramadol, linezolid, triptans) due to serotonin syndrome risk. Use with caution with drugs that prolong QT interval.

Missed dose

If a dose is missed, it should be taken as soon as remembered unless it is close to the time of the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule resumed. Doubling the dose to make up for a missed one is not recommended.

Overdose

Symptoms of overdose may include nausea, vomiting, drowsiness, dizziness, tachycardia, and lethargy. Severe overdose may lead to coma, seizures, ECG changes, or serotonin syndrome. There is no specific antidote; treatment is supportive and symptomatic. Gastric lavage and activated charcoal may be considered if presented early. Ensure adequate airway and monitor cardiac and vital signs. Contact a poison control center immediately.

Storage

Store at controlled room temperature (20–25°C or 68–77°F). Keep in a tightly closed container, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

Clinical trials and post-marketing surveillance have consistently demonstrated Luvox’s efficacy in reducing OCD symptoms, with many patients experiencing a 25–40% reduction in Y-BOCS scores. Patient reviews often highlight significant improvements in quality of life and reduction in compulsive behaviors, though side effects such as nausea and sexual dysfunction are frequently reported. Physician assessments note its utility in treatment-resistant cases and its favorable profile in pediatric populations when carefully monitored.