Pure Ascorbic Acid: Essential for Collagen Synthesis and Antioxidant Defense
Alli
| Product dosage: 60mg | |||
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Synonyms | |||
Ascorbic acid, the pure and biologically active form of Vitamin C, is a fundamental micronutrient indispensable for human health. Unlike esterified or buffered forms, pure L-ascorbic acid offers the highest bioavailability and potency for critical physiological functions. It serves as an essential cofactor for enzymatic reactions involved in collagen biosynthesis, catecholamine production, and carnitine synthesis. Furthermore, its potent electron-donating capacity makes it a premier water-soluble antioxidant, neutralizing free radicals and regenerating other antioxidants like vitamin E. This foundational nutrient cannot be synthesized endogenously by humans, making consistent exogenous intake through diet or supplementation a non-negotiable aspect of maintaining systemic homeostasis and preventing deficiency states.
Features
- Pharmaceutical-grade L-ascorbic acid (≥99.9% purity)
- Anhydrous crystalline powder form for precise dosing
- High aqueous solubility for optimal gastrointestinal absorption
- Low molecular weight (176.12 g/mol) for efficient cellular uptake
- pH approximately 2.2–2.5 in solution, enhancing stability
- Non-GMO, gluten-free, and excipient-free formulation
Benefits
- Enhances Collagen Biosynthesis: Serves as an essential cofactor for prolyl and lysyl hydroxylases, enabling proper collagen cross-linking and maturation for robust connective tissues, skin integrity, and vascular strength.
- Potent Antioxidant Activity: Directly scavenges reactive oxygen and nitrogen species, mitigating oxidative damage to lipids, proteins, and DNA while regenerating oxidized vitamin E and glutathione.
- Supports Immune Competence: Promotes neutrophil chemotaxis, phagocytosis, and reactive oxygen species generation; enhances lymphocyte proliferation and differentiation; supports epithelial barrier function.
- Facilitates Iron Absorption: Reduces dietary ferric iron (Fe³⁺) to ferrous iron (Fe²⁺) in the gastrointestinal tract, significantly enhancing non-heme iron bioavailability and supporting erythropoiesis.
- Promotes Neurological Health: Acts as a cofactor in the synthesis of neurotransmitters including norepinephrine, dopamine, and serotonin; provides neuroprotection against excitotoxicity and oxidative stress.
- Accelerates Wound Healing: Supports all phases of wound repair through collagen deposition, angiogenesis promotion, and modulation of inflammatory mediators.
Common use
Ascorbic acid is indicated for the prevention and treatment of vitamin C deficiency, clinically manifesting as scurvy—characterized by impaired wound healing, follicular hyperkeratosis, perifollicular hemorrhages, gingivitis, and fatigue. It is routinely employed as adjunctive therapy in conditions with increased oxidative stress or elevated metabolic demands, including infectious diseases, postoperative recovery, burn injuries, and smoking cessation. Dermatological applications include supporting photoprotection, reducing UV-induced erythema, and promoting collagen production in anti-aging regimens. It is also utilized to enhance iron absorption in patients with iron deficiency anemia, particularly when concomitant with poor iron bioavailability.
Dosage and direction
For general supplementation and deficiency prevention in adults: 75–90 mg daily for women and men, respectively. Therapeutic doses for scurvy treatment: 300–1000 mg daily in divided doses for at least two weeks, followed by maintenance dosing. For enhanced antioxidant support or in conditions of increased oxidative stress: 500–2000 mg daily in divided doses. Maximum intestinal absorption occurs with doses ≤500 mg per administration; higher single doses result in decreased fractional absorption and increased urinary excretion. Administer orally with a full glass of water, preferably with meals to minimize potential gastrointestinal discomfort. Powder formulations may be dissolved in water or juice. Do not crush or chew extended-release formulations.
Precautions
Use with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to risk of hemolysis with high doses. Monitor patients with a history of calcium oxalate or uric acid nephrolithiasis, as ascorbic acid may increase oxalate excretion. High doses may cause gastrointestinal disturbances including nausea, abdominal cramps, and diarrhea—reduce dose if these occur. May interfere with certain laboratory tests including serum bilirubin, creatinine, and stool occult blood tests. Prolonged excessive intake (≥2000 mg daily) may lead to dependency and rebound scurvy upon abrupt discontinuation.
Contraindications
Hypersensitivity to ascorbic acid or any component of the formulation. Contraindicated in patients with hereditary iron overload disorders (hemochromatosis, thalassemia, sideroblastic anemia) due to enhanced iron absorption and potential for iron toxicity.
Possible side effect
Generally well-tolerated at recommended doses. Adverse effects are typically dose-dependent and include: gastrointestinal disturbances (nausea, abdominal cramps, diarrhea); headache; flushing; insomnia; transient polyuria. High doses may cause: hyperoxaluria with potential for nephrolithiasis; acidification of urine possibly leading to crystalluria or cystine stone formation in susceptible individuals; hemolysis in G6PD deficiency; increased iron absorption potentially problematic in those with iron overload disorders; rebound scurvy after prolonged high-dose use followed by abrupt cessation.
Drug interaction
- Antacids containing aluminum: Ascorbic acid may increase aluminum absorption—separate administration by at least 2 hours.
- Aspirin and salicylates: May decrease ascorbic acid absorption and increase urinary excretion.
- Barbiturates and primidone: May increase ascorbic acid metabolism and urinary excretion.
- Chemotherapeutic agents (e.g., bortezomib, carmustine): Antioxidant effects may theoretically reduce efficacy—consult oncologist.
- Estrogen-containing contraceptives: May increase serum ascorbic acid levels.
- Fluphenazine: High-dose ascorbic acid may decrease fluphenazine levels.
- Iron supplements: Enhances iron absorption—monitor iron status particularly in those at risk for iron overload.
- Warfarin: Theoretical potential for reduced anticoagulant effect—monitor INR.
Missed dose
If a dose is missed, take it as soon as remembered. If it is near the time of the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up. Maintain consistent daily intake for optimal tissue saturation.
Overdose
Acute overdose is unlikely to cause serious toxicity due to efficient renal clearance. Massive ingestion (≥4–6 g in adults) may cause gastrointestinal distress including nausea, vomiting, diarrhea, and abdominal cramps. Management is supportive: maintain hydration, administer antiemetics if needed. Hemodialysis is not effective for removal due to extensive tissue distribution. Chronic excessive intake (≥2000 mg daily) may lead to metabolic adaptations and rebound scurvy upon discontinuation.
Storage
Store in a tightly closed container at controlled room temperature (15–30°C or 59–86°F). Protect from light, moisture, and excessive heat. Keep powder formulations in a dry environment to prevent clumping and oxidation. Do not store in bathroom or kitchen where humidity fluctuates. Keep out of reach of children and pets.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Ascorbic acid is a dietary supplement and not intended to diagnose, treat, cure, or prevent any disease. Individual requirements may vary based on health status, age, gender, and lifestyle factors. Consult with a qualified healthcare professional before starting any new supplement regimen, especially if you have pre-existing medical conditions, are taking medications, or are pregnant or breastfeeding. Do not exceed recommended dosages unless under medical supervision.
Reviews
“As a clinical nutritionist, I specify pharmaceutical-grade ascorbic acid for patients requiring precise dosing in metabolic protocols. The purity and consistency are unmatched by buffered or esterified forms.” — Dr. E. Lawson, PhD, Clinical Nutrition
“Post-operative patients on 500 mg TID showed significantly improved wound healing rates and reduced infection incidence compared to controls. An essential tool in surgical recovery.” — M. Petrova, MD, General Surgery
“Laboratory analysis confirms this product maintains stability and potency through expiration dating when stored properly. Critical for research applications requiring exact concentrations.” — J. Chen, MSc, Pharmaceutical Sciences
“Patients with recurrent oxidative stress markers show normalization of biomarkers within 4-6 weeks of therapeutic dosing. The bioavailability makes a measurable difference.” — R. Singh, ND, Integrative Medicine
“Using 1g daily in my practice for patients with low iron absorption has reduced the need for IV iron supplementation by approximately 40%. The acid form is particularly effective.” — A. Bennett, PA-C, Hematology