Retin A 0.05%: Advanced Topical Retinoid for Skin Renewal
Retin A 0,05
| Product dosage: 20g | |||
|---|---|---|---|
| Package (num) | Per tube | Price | Buy |
| 3 | $23.33 | $70.00 (0%) | 🛒 Add to cart |
| 10 | $15.00 | $233.33 $150.00 (36%) | 🛒 Add to cart |
| 15 | $13.80 | $350.00 $207.00 (41%) | 🛒 Add to cart |
| 20 | $13.20
Best per tube | $466.67 $264.00 (43%) | 🛒 Add to cart |
Synonyms | |||
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Retin A 0.05% cream contains tretinoin, a potent vitamin A derivative clinically proven to address multiple dermatological concerns through cellular renewal. This prescription-strength formulation works at the molecular level to normalize keratinization, reduce comedone formation, and stimulate collagen production. It represents a cornerstone in dermatological therapy for both acne vulgaris and photoaging, offering a scientifically validated approach to improving skin texture, tone, and overall health. Proper application under medical supervision can yield significant, long-lasting improvements in cutaneous appearance and function.
Features
- Active ingredient: Tretinoin 0.05% in micronized form for enhanced penetration
- Vehicle: Oil-in-water emulsion base with emollient properties
- pH-balanced formulation (5.5-6.0) to maintain skin barrier integrity
- Preservative system: Paraben-free stabilization
- Non-comedogenic and hypoallergenic testing
- Packaging: Airless pump technology to prevent oxidation and contamination
- Stability: 24-month shelf life when stored properly
Benefits
- Significantly reduces inflammatory and non-inflammatory acne lesions through follicular canal normalization
- Diminishes the appearance of fine lines and wrinkles by stimulating Type I and III collagen synthesis
- Improves skin texture and tone through enhanced epidermal turnover and dispersion of melanin granules
- Reduces hyperpigmentation and evens skin complexion by inhibiting melanosome transfer
- Prevents new comedone formation by maintaining follicular patency
- Increases skin thickness and elasticity through dermal remodeling
Common use
Retin A 0.05% is primarily indicated for the topical treatment of acne vulgaris, particularly in cases involving comedones, papules, and pustules. It is equally effective for addressing photoaging concerns including fine wrinkles, mottled hyperpigmentation, and rough skin texture resulting from chronic sun exposure. Dermatologists frequently prescribe this concentration for patients who have developed tolerance to lower strengths (0.025%) but require enhanced efficacy without moving to the highest concentration (0.1%). The medication is suitable for off-label use in treating certain forms of keratosis pilaris and pitryasis rubra pilaris when standard therapies prove insufficient.
Dosage and direction
Apply a pea-sized amount to the entire affected area once daily, preferably in the evening. Begin with application every second or third night for the first two weeks to assess tolerance. Gently cleanse skin with a mild, non-medicated cleanser and pat dry before application. Wait 20-30 minutes after washing to ensure complete dryness, as application to damp skin increases penetration and potential irritation. Spread thinly and evenly, avoiding the eye area (including eyelids), nasolabial folds, and mucous membranes. Morning application should include broad-spectrum sunscreen with SPF 30 or higher due to increased photosensitivity. Treatment response typically becomes apparent after 2-3 weeks, with significant improvement occurring after 6-12 weeks of continuous therapy.
Precautions
Discontinue use if hypersensitivity reactions occur, including severe erythema, blistering, or crusting. Patients with eczema, seborrheic dermatitis, or other skin conditions involving compromise of the epidermal barrier should use with extreme caution. Avoid concomitant use of abrasive cleansers, astringents, or products containing alcohol, spices, or lime. Weather extremes, especially wind and cold, may increase susceptibility to irritation. Patients with sunburn should delay treatment until complete recovery. This medication may cause initial flare-up of acne during the first few weeks of treatment as microcomedones are expelled. Contact with eyes, mouth, angles of the nose, and mucous membranes must be avoided. Not recommended for use on sunburned skin or open wounds.
Contraindications
Absolute contraindications include hypersensitivity to tretinoin or any component of the formulation. Should not be used by patients with a history of eczema, rosacea, or cutaneous lupus erythematosus. Contraindicated during pregnancy (Category C) and breastfeeding due to potential systemic absorption and teratogenic risk. Not recommended for patients undergoing radiation therapy or using photosensitizing drugs. Avoid in patients with acute inflammatory skin conditions including poison ivy, poison oak, or herpes simplex lesions. Contraindicated in cases where the skin barrier is significantly compromised, such as severe burns or extensive denudation.
Possible side effects
Expected initial reactions include erythema, peeling, dryness, and burning sensation (retinization period), which typically subside within 2-4 weeks of continued use. More significant reactions may include severe stinging or burning, blistering, crusting, and edema. Hyperpigmentation or hypopigmentation may occur, particularly in patients with darker skin tones. Photosensitivity reactions are common, necessitating strict sun protection. Rare reports include contact allergy, skin atrophy, and telangiectasia with prolonged use. Paradoxical acne flare may occur during the initial weeks as microcomedones surface. Temporary hair texture changes have been reported when applied to hairy areas.
Drug interaction
Concurrent use with other topical acne medications (benzoyl peroxide, salicylic acid, azelaic acid) may increase irritation potential—space applications by several hours. Avoid combination with topical antibiotics unless specifically directed by a physician. Enhanced absorption and potential systemic effects may occur when used with agents that increase skin permeability (dimethyl sulfoxide). Photosensitizing medications (tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) may compound photosensitivity reactions. Exercise caution when using with topical corticosteroids due to potential barrier impairment. Avoid concomitant use with abrasive or exfoliating agents.
Missed dose
Apply as soon as remembered if still on the same day. If remembered the next day, skip the missed dose and resume regular schedule. Do not double application to make up for missed dose. Consistency in application yields better results than occasional intensive use. If multiple doses are missed, consider reinitiating therapy with reduced frequency to reacclimatize skin. Maintain a regular application schedule for optimal therapeutic outcomes.
Overdose
Topical overdose may result in severe erythema, peeling, discomfort, and edema. Treatment involves immediate discontinuation and symptomatic management with cool compresses and emollients. Oral ingestion, though rare due to topical formulation, may produce symptoms consistent with hypervitaminosis A: headache, dizziness, nausea, vomiting, and skin desquamation. In case of accidental ingestion, seek immediate medical attention. Gastrointestinal decontamination and supportive care are mainstays of management. The oil-in-water emulsion base may cause lipid pneumonia if aspirated.
Storage
Store at controlled room temperature (15-30°C or 59-86°F). Keep tube tightly closed and upright. Protect from light and freezing. Do not store in bathroom where moisture and heat may degrade the formulation. Keep pump mechanism clean to prevent contamination. Discard 60 days after opening to ensure stability and efficacy. Keep out of reach of children and pets. Do not transfer to other containers.
Disclaimer
This information does not replace professional medical advice. Consult a qualified healthcare provider for diagnosis and appropriate treatment decisions. Individual results may vary based on skin type, condition severity, and adherence to treatment protocol. The manufacturer is not liable for incorrect usage or adverse outcomes resulting from improper application. Prescription required—use only under medical supervision.
Reviews
Clinical studies demonstrate 70-80% reduction in acne lesions after 12 weeks of consistent use. Dermatologist surveys indicate 85% patient satisfaction for photoaging improvement when combined with sun protection. Patient-reported outcomes show significant improvement in skin texture and tone within 8-10 weeks. Long-term users report maintained efficacy with proper skincare regimen. Some patients note initial purging phase before visible improvements. Higher concentration (0.05%) shows faster results than 0.025% with manageable irritation profile in acclimated patients.