Tenovate: Potent Topical Corticosteroid for Rapid Inflammatory Relief
Tenovate
| Product dosage: 15g | |||
|---|---|---|---|
| Package (num) | Per tube | Price | Buy |
| 4 | $10.50 | $42.00 (0%) | 🛒 Add to cart |
| 5 | $10.00 | $52.50 $50.00 (5%) | 🛒 Add to cart |
| 6 | $9.83 | $63.00 $59.00 (6%) | 🛒 Add to cart |
| 7 | $9.43 | $73.50 $66.00 (10%) | 🛒 Add to cart |
| 8 | $9.00 | $84.00 $72.00 (14%) | 🛒 Add to cart |
| 9 | $8.44 | $94.50 $76.00 (20%) | 🛒 Add to cart |
| 10 | $8.20
Best per tube | $105.00 $82.00 (22%) | 🛒 Add to cart |
Tenovate (clobetasol propionate) is a high-potency topical corticosteroid formulation indicated for the short-term treatment of moderate to severe corticosteroid-responsive dermatoses. As a Class I super-potent topical steroid, it exerts potent anti-inflammatory, antipruritic, and vasoconstrictive effects through multiple mechanisms of action. This medication is reserved for cases where less potent corticosteroids have proven inadequate and requires careful medical supervision to balance its significant efficacy with appropriate safety considerations. Tenovate represents a valuable tool in the dermatological armamentarium for managing severe inflammatory skin conditions when used according to established treatment guidelines.
Features
- Contains 0.05% clobetasol propionate as the active pharmaceutical ingredient
- Available in multiple formulations including cream, ointment, gel, and solution
- Rapid percutaneous absorption with high receptor affinity
- Formulated with optimized vehicle systems for enhanced drug delivery
- Manufactured under strict pharmaceutical quality control standards
- Packaged in tamper-evident containers with appropriate child-resistant features
- Clear expiration dating and batch tracking information
- Multiple package sizes (15g, 30g, 60g) for treatment flexibility
Benefits
- Provides rapid relief from inflammation, itching, and erythema within days of initiation
- Effectively manages severe dermatological conditions that are unresponsive to milder corticosteroids
- Multiple formulation options allow for tailored treatment based on lesion type and body area
- Short treatment courses often produce sustained remission periods
- Reduces scratching and secondary infection risk through effective pruritus control
- Minimizes psychological distress associated with severe visible dermatoses
Common use
Tenovate is primarily indicated for the short-term treatment of severe inflammatory skin conditions including psoriasis (particularly plaque psoriasis), resistant eczemas (including nummular eczema and lichen simplex chronicus), discoid lupus erythematosus, and other corticosteroid-responsive dermatoses. It may also be used under specialist supervision for conditions such as lichen planus, granuloma annulare, and certain forms of alopecia. The medication is typically reserved for cases where less potent corticosteroids have failed to provide adequate control of symptoms.
Dosage and direction
Apply a thin film of Tenovate to the affected area once or twice daily, depending on severity and physician recommendation. The total weekly dosage should not exceed 50g for adults. Treatment duration is generally limited to 2-4 weeks maximum, with many conditions showing significant improvement within the first week. For scalp conditions, the solution formulation should be applied sparingly to affected areas twice daily. Occlusive dressings may be used for limited periods in severe cases under medical supervision but significantly increase systemic absorption risk. Hands should be washed thoroughly after application unless being treated.
Precautions
Use Tenovate with caution in patients with liver impairment, diabetes mellitus, or thyroid disorders. Avoid application to the face, groin, axillae, or other intertriginous areas due to increased absorption and side effect risk. Monitor for signs of hypothalamic-pituitary-adrenal (HPA) axis suppression during prolonged use or when applied to large body surface areas. Periodic evaluation for ocular changes (glaucoma, cataracts) is recommended with extended periorbital use. Use cautiously in pediatric and geriatric populations due to increased systemic absorption potential.
Contraindications
Tenovate is contraindicated in patients with known hypersensitivity to clobetasol propionate or any formulation components. Absolute contraindications include viral skin infections (herpes simplex, varicella), fungal infections, tuberculous skin lesions, and untreated bacterial skin infections. Should not be used on rosacea, acne vulgaris, or perioral dermatitis. Contraindicated in patients with widespread plaque psoriasis undergoing phototherapy. Not recommended during pregnancy unless potential benefits outweigh risks, and generally avoided during lactation.
Possible side effect
Common local reactions include burning sensation, itching, irritation, dryness, folliculitis, hypertrichosis, and skin atrophy. More significant effects may include striae, telangiectasia, hypopigmentation, and contact dermatitis. Systemic absorption can lead to HPA axis suppression manifesting as hyperglycemia, glucosuria, Cushing’s syndrome, and delayed weight gain in children. Ocular application may cause glaucoma, optic nerve damage, or cataract formation. Rebound flare of dermatosis may occur following discontinuation, particularly with abrupt cessation.
Drug interaction
Increased systemic absorption may occur when used with occlusive dressings. Concurrent use with other corticosteroids (oral, inhaled, or topical) may produce additive effects and increase risk of HPA axis suppression. May interact with drugs that affect corticosteroid metabolism or clearance. Use with caution in patients taking medications that affect skin integrity or immune response. No well-documented interactions with specific drugs, but systemic effects could potentially interact with diabetic medications, anticoagulants, or other drugs affected by adrenal function.
Missed dose
If a dose is missed, apply it as soon as remembered unless it is nearly time for the next application. Do not double the dose to make up for a missed application. Maintain the regular application schedule once resumed. Consistent application is important for therapeutic efficacy, but occasional missed doses are unlikely to significantly impact treatment outcomes given the medication’s mechanism of action.
Overdose
Topical overdose may produce severe local skin reactions including intensified side effects. Systemic absorption in excessive amounts can lead to symptoms of hypercorticism including moon face, central obesity, hypertension, and hyperglycemia. Treatment involves discontinuation of the medication and supportive care. Acute massive overdose may require monitoring of adrenal function and appropriate medical management of corticosteroid excess symptoms. There is no specific antidote; treatment is symptomatic and supportive.
Storage
Store at controlled room temperature (20-25°C or 68-77°F). Keep container tightly closed when not in use. Protect from excessive heat and direct sunlight. Do not freeze. Keep out of reach of children and pets. Do not use after the expiration date printed on packaging. Properly discard any medication that has changed color, consistency, or shows signs of contamination.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Tenovate is a prescription medication that should be used only under the supervision of a qualified healthcare professional. Individual response to treatment may vary, and proper diagnosis should precede any therapeutic intervention. Patients should consult their healthcare provider for personalized medical advice and report any adverse reactions promptly.
Reviews
Clinical studies demonstrate Tenovate’s efficacy in managing severe dermatological conditions, with approximately 85% of psoriasis patients showing significant improvement within two weeks. Dermatologists consistently rate it as highly effective for short-term management of inflammatory skin conditions, though emphasize the importance of appropriate patient selection and treatment duration limits. Patient satisfaction surveys indicate high levels of symptom relief, though some report concerns about potential side effects with prolonged use. The medication maintains its position as a benchmark high-potency topical corticosteroid in dermatological practice.